*Co-first author, #Co-corresponding author
2024
Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.
Dodd DO, Mechaussier S, Yeyati PL, McPhie F, Anderson JR, Khoo CJ, Shoemark A, Gupta DK, Attard T, Zariwala MA, Legendre M, Bracht D, Wallmeier J, Gui M, Fassad MR, Parry DA, Tennant PA, Meynert A, Wheway G, Fares-Taie L, Black HA, Mitri-Frangieh R, Faucon C, Kaplan J, Patel M, McKie L, Megaw R, Gatsogiannis C, Mohamed MA, Aitken S, Gautier P, Reinholt FR, Hirst RA, O'Callaghan C, Heimdal K, Bottier M, Escudier E, Crowley S, Descartes M, Jabs EW, Kenia P, Amiel J, Bacci GM, Calogero C, Palazzo V, Tiberi L, Blümlein U, Rogers A, Wambach JA, Wegner DJ, Fulton AB, Kenna M, Rosenfeld M, Holm IA, Quigley A, Hall EA, Murphy LC, Cassidy DM, von Kriegsheim A; Scottish Genomes Partnership16; Genomics England Research Consortium45; Undiagnosed Diseases Network46; Papon JF, Pasquier L, Murris MS, Chalmers JD, Hogg C, Macleod KA, Urquhart DS, Unger S, Aitman TJ, Amselem S, Leigh MW, Knowles MR, Omran H, Mitchison HM, Brown A, Marsh JA, Welburn JPI, Ti SC, Horani A, Rozet JM, Perrault I, Mill P.
Science. 2024 Apr 26;384(6694):eadf5489. doi: 10.1126/science.adf5489
Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.
Li Z, Li Z, Zhang Y, Zhou L, Xu Q, Li L, Zeng L, Xue J, Niu H, Zhong J, Yu Q, Li D, Gui M, Huang Y, Tu S, Zhang Z, Song CQ, Wu J, Shen EZ.
Nat Struct Mol Biol. 2024 Apr 24. doi: 10.1038/s41594-024-01287-6
2023
Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M#, Gui M#, Wu J#. Cell. 2023 Jun 22;186(13):2897-2910.e19. doi: 10.1016/j.cell.2023.05.009. **Preview in Cell by Muneyoshi Ichikawa **News & Views by Katarzyna Ciazynska in Nature Structural & Molecular Biology **Highlighted by Liangzhu Laboratory and BioArt
Axonemal structures reveal mechanoregulatory and disease mechanisms. Walton T*, Gui M*, Velkova S, Fassad MR, Hirst RA, Haarman E, O'Callaghan C, Bottier M, Burgoyne T, Mitchison HM, Brown A. Nature. 2023 Jun;618(7965):625-633. doi: 10.1038/s41586-023-06140-2 **Research Briefings in Nature **Highlighted by UCL and BioArt
2022
Mechanism of IFT-A polymerization into trains for ciliary transport.
Meleppattu S, Zhou H, Dai J, Gui M, Brown A.
Cell. 2022 Dec 22;185(26):4986-4998.e12. doi: 10.1016/j.cell.2022.11.033
SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
Gui M, Croft JT, Zabeo D, Acharya V, Kollman JM, Burgoyne T, Höög JL, Brown A.
Proc Natl Acad Sci U S A. 2022, 119(41):e2207605119. https://doi.org/10.1073/pnas.2207605119
Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Gui M, Wang X, Dutcher SK, Brown A, Zhang R. Nat Struct Mol Biol. 2022, 29: 483–492. https://doi.org/10.1038/s41594-022-00770-2 **Highlighted by Elena Zehr and Antonina Roll-Mecak in News & Views of Nat Struct Mol Biol (29, 416-418 (2022))
2021
De novo identification of mammalian ciliary motility proteins using cryo-EM. Gui M*, Farley H*, Anujan P*, Anderson JR*, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK, Zhang Q, Bingle CD, Norris DP, Roy S, Brown A. Cell. 2021, 11;184(23):5791-5806.e19. https://doi.org/10.1016/j.cell.2021.10.007 **Research highlight by Florian Ullrich in Nat Struct Mol Biol (28, 958 (2021))
Structures of radial spokes and associated complexes important for ciliary motility. Gui M, Ma M, Sze-Tu E, Wang X, Koh F, Zhong ED, Berger B, Davis JH, Dutcher SK, Zhang R, Brown A. Nat Struct Mol Biol. 2021, 28(1):29-37. https://doi.org/10.1038/s41594-020-00530-0 **Featured cover story (Volume 28 Issue 1, January 2021).
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Zhang M*, Gui M*, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZY, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G. Nat Struct Mol Biol. 2021, 28, 258–267. https://doi.org/10.1038/s41594-020-00554-6 **Recommended by Faculty Opinions **Highlighted by Jagannath Maharana and Arun K. Shukla in News & Views of Nat Struct Mol Biol (28, 331–333 (2021))
2020
Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Gao J, Gui M#, Xiang Y#. PLoS Pathog. 2020, 16(11):e1009062. https://doi.org/10.1371/journal.ppat.1009062
Structure and activation mechanism of the BBSome membrane protein trafficking complex. Singh SK, Gui M, Koh F, Yip MC, Brown A. Elife. 2020, 9:e53322. https://doi.org/10.7554/eLife.53322 **Recommended by Faculty Opinions
Before 2019
Structural assembly of the tailed bacteriophage φ29.
Xu J, Wang D, Gui M, Xiang Y.
Nat Commun. 2019, 10(1):2366. https://doi.org/10.1038/s41467-019-10272-3
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2.
Song W*, Gui M*, Wang X, Xiang Y.
PLoS Pathog. 2018 Aug 13;14(8):e1007236. https://doi.org/10.1371/journal.ppat.1007236
**The most cited paper of PLoS Pathogens in 2018
Electron Microscopy Studies of the Coronavirus Ribonucleoprotein Complex.
Gui M, Liu X, Guo D, Zhang Z, Yin C, Chen Y, Xiang Y.
Protein Cell. 2017, 8(3):219-224. https://doi.org/10.1007/s13238-016-0352-8
Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding.
Gui M*, Song W*, Zhou H, Xu J, Chen S, Xiang Y and Wang X.
Cell Res. 2017, 27(1):119-129. https://doi.org/10.1038/cr.2016.152
Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
Misasi J*, Gilman MS*, Kanekiyo M*, Gui M*, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ and McLellan JS.
Science. 2016, 351(6279): 1343-6. https://doi.org/10.1126/science.aad6117
**Recommended by Faculty Opinions
The bacteriophage phi29 tail possesses a pore-forming loop for cell membrane penetration.
Xu J, Gui M, Wang D and Xiang Y.
Nature. 2016, 534(7608): 544-7. https://doi.org/10.1038/nature18017
Potent neutralizing monoclonal antibodies against Ebola virus infection.
Zhang Q*, Gui M*, Niu X, He S, Wang R, Feng Y, Kroeker A, Zuo Y, Wang H, Wang Y, Li J, Li C, Shi Y, Shi X, Gao GF, Xiang Y, Qiu X, Chen L and Zhang L.
Sci Rep. 2016, 6: 25856. https://doi.org/10.1038/srep25856
The interactions between mitochondria and sarcoplasmic reticulum and the proteome characterization of mitochondrion associated membrane from rabbit skeletal muscle.
Liu Z, Du X, Deng J, Gu M, Hu H, Gui M, Yin CC and Chang Z.
Proteomics. 2015, 15(15): 2701-4. https://doi.org/10.1002/pmic.201400493