Miao Gui Laboratory

Congrats to Qi for his recent publication in Nat Commun. We revealed the function of sperm doublet microtubule-associated Tektin1, Tektin5, DUSP21 and TSSK6. Surprisingly, these proteins have very diserve roles in regulating sperm motility and integrity. We also esteblisehd Tektin1 as a MIVA gene and TSSK6 as a likely MMAF gene. Congratulations to LIU Qi … Read more

On September 22nd, we explored Jingshan and were rewarded with stunning views and delicious local cuisine. The Jingshan Ancient Path (径山古道) proved quite a challenge, yet we successfully reached the mountain top.

Some new lab photos by a prefessional photographer. So cool!

Huge congrats to LIU Qi for his new paper entitled “In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells” being published in Nat Commun. This is a wonderful collabration with Qiang and Xueliang. Also super excited that LIU Qi got the Chinese postdoctoral fellowship — his first … Read more

LI Bo left the Gui lab to resume his traditional Chinese medicine career. As the first lab member, Bo has made a great contribution to the lab including lab management and experiments. We wish him all the best in his new adventure.

During the week of Feb 17th, Miao was invited to give a talk titled “Cilia diversity from ultrastructure” at 2025 GRC Cilia, Mucus and Mucociliary Interactions in Pomona, California. It’s really great to meet old friends and make new friends. Interestingly, although I have been in touch with many of them, this is the first … Read more

On September 30th, our lab went for a BOWLING afternoon (as well as other wonderful entertainments) to welcome the beautiful autumn and to celebrate the National Day.

On July 11th, Miao went to Shanghai to attend the ceremony of MIT TR35 China and gave a speech. Surprisely, Qian Wang, a close friend also won this prize and I did not know until I saw Lihong in the ceremony lol. https://mp.weixin.qq.com/s/oDZa9i7YT3g1JucgPoSyCg https://tr35.mittrchina.com/annual-winner?title=2023 https://mp.weixin.qq.com/s/Wq0AvgZa-JGTxrEYBmqv5A

Dongqin and Yejun have joined our lab recently. Our team is growing!

The Science paper is a collaboration with Pleasantine Mill in which we contributed to confirm the tubulin isotopes in cilia by high-resolution cryo-EM and to map the mutations in the structure. doi: 10.1126/science.adf5489 The other work is a collaboration with Jianping Wu (the second time) that was published in Nat Struct Mol Biol. doi: 10.1038/s41594-024-01287-6