Delicious yakiniku

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To celebrate the upcoming Chinese New Year, the Gui lab went out for a dinner on Jan 30th. The barbecue was amazing! Thank everyone for the hard work in 2023 and we can’t wait to see what we will achieve in 2024, the year of Dragon.

Welcome Qi and Yuqi

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Two postdocs Qi Liu and Yuqi Liu have joined Gui lab. Looking forward to the uncoming great science! Huang has left our lab. Best wishes to him.

Winter hiking

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Today, the Gui lab went hiking with the Xie/Zhou lab at Yunxizhujing (云栖竹径), which is known for the beautiful bamboos and green tea trees. Shout out to the warriors as today is -5℃, probably the coldest day of the year.

Alexey’s visit

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On Nov 1st, Dr. Alexey Amunts from Stockholm University in Sweden visited our lab and gave a wonderful talk “how genes become machines in mitochondria”. Alexey shared his work on mitochondrial ribosome which he started back to 2013 (together with Miao’s postdoc supervisor Alan Brown) when he was a postdoc in the lab of Nobel … Read more

Lab dinner

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On Sep 8th, 2023, we had a delicious hotpot and enjoyed the board game and karaokay very much! Thank all for the sparkling Teacher’s day cake!

Shuo joined.

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Shuo just got her Master’s degree at South China University of Technology and joined our lab as a research assistant. Welcome!

Research highlights

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Lots of exciting things recently! Miao’s biography by Liangzhu laboratory The sperm DMT paper is highlighted by Liangzhu laboratory and BioArt The axoneme structures is briefed in Nature and promoted in BioArt. See also the report by University College London

Cell paper! Sperm DMT and male infertility

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The first publication of the Gui lab is online in Cell. We revealed the structures of mouse and human sperm DMTs and identified many sperm-specific microtubule inner proteins (MIPs). Moreover, combining whole exome sequencing and cell biological analysis, we identified a new subtype of asthenozoospermia, MIVA (MIP-variant-associated asthenozoospermia). This was a great collaboration with Jianping … Read more

Revealing the atomic detail of the ciliary skeleton

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Miao’s postdoc work in the Brown lab has been online on Nature. https://www.nature.com/articles/s41586-023-06140-2 This work uncovered the structures of axoneme from Chlamydomonas reinhardtii flagella and human respiratory cilia. The ~200 proteins identified in our study have implications for PCD/MMAF diagnosis. We also revealed how gene mutations affect ciliary motility and structure by checking the respiratory … Read more

Welcome Huang, our first postdoc!

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We are delighted to welcome Huang to join the Gui lab. Huang worked on the actin-based stereocilia in the inner ear during his Ph.D. He will be looking into the microtubule-based cilia.