Miao Gui Laboratory

On Nov 1st, Dr. Alexey Amunts from Stockholm University in Sweden visited our lab and gave a wonderful talk “how genes become machines in mitochondria”. Alexey shared his work on mitochondrial ribosome which he started back to 2013 (together with Miao’s postdoc supervisor Alan Brown) when he was a postdoc in the lab of Nobel … Read more

On Sep 8th, 2023, we had a delicious hotpot and enjoyed the board game and karaokay very much! Thank all for the sparkling Teacher’s day cake!

Shuo just got her Master’s degree at South China University of Technology and joined our lab as a research assistant. Welcome!

Lots of exciting things recently! Miao’s biography by Liangzhu laboratory The sperm DMT paper is highlighted by Liangzhu laboratory and BioArt The axoneme structures is briefed in Nature and promoted in BioArt. See also the report by University College London

The first publication of the Gui lab is online in Cell. We revealed the structures of mouse and human sperm DMTs and identified many sperm-specific microtubule inner proteins (MIPs). Moreover, combining whole exome sequencing and cell biological analysis, we identified a new subtype of asthenozoospermia, MIVA (MIP-variant-associated asthenozoospermia). This was a great collaboration with Jianping … Read more

Miao’s postdoc work in the Brown lab has been online on Nature. https://www.nature.com/articles/s41586-023-06140-2 This work uncovered the structures of axoneme from Chlamydomonas reinhardtii flagella and human respiratory cilia. The ~200 proteins identified in our study have implications for PCD/MMAF diagnosis. We also revealed how gene mutations affect ciliary motility and structure by checking the respiratory … Read more

We are delighted to welcome Huang to join the Gui lab. Huang worked on the actin-based stereocilia in the inner ear during his Ph.D. He will be looking into the microtubule-based cilia.

On April 10th, Bo and Miao started the bench work.

Miao was presenting at the 4th National Cilia and Ciliopathies Conference on April 1st at Hangzhou. Very happy to make lots of new friends and discuss science in person. Bo and Xixi also enjoyed the conference and shared some exiting moments at our group meeting.

The first lab dinner on the last day of Febrary. Bo, Xixi and me enjoyed the seafood buffet a lot!