Revealing the atomic detail of the ciliary skeleton

Miao’s postdoc work in the Brown lab has been online on Nature. https://www.nature.com/articles/s41586-023-06140-2

This work uncovered the structures of axoneme from Chlamydomonas reinhardtii flagella and human respiratory cilia. The ~200 proteins identified in our study have implications for PCD/MMAF diagnosis. We also revealed how gene mutations affect ciliary motility and structure by checking the respiratory cilia isolated from four PCD patients.

It’s a close collaboration with Travis, Tom, Hannah and team. As always, Alan led the whole project!